Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients.

نویسندگان

  • Juan José Díez
  • Maurizio Bossola
  • María José Fernández-Reyes
  • Enrico Di Stasio
  • Luigi Tazza
  • Giovanna Luciani
  • Rosa Codoceo
  • Pedro Iglesias
  • Astrid Rodríguez
  • Elena González
  • Rafael Selgas
چکیده

BACKGROUND We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD). METHODS 118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All patients had baseline measurement of serum leptin concentrations. Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis. RESULTS The leptin/BMI ratio was similar in patients with and without CVD at baseline (0.65 [0.29-2.23] vs. 0.68 [0.29-1.49] ng·m2/ml·kg, respectively, NS). Multiple logistic regression analysis showed that there was not an independent association between leptin/BMI ratio and prevalent CVD. During the follow-up time, 52 (44.1%) patients died. CVD was the cause of death in 27 out of 52 (51.9%) deceased patients. Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin/BMI ratio and all-cause and CVD-related mortality. CONCLUSION These results do not support that, in stable HD patients, serum leptin concentrations and the leptin/BMI ratio are related with prevalent CVD. Leptin/BMI ratio seems not to be a risk factor for mortality in these patients.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of leptin with mortality in patients on maintenance hemodialysis: a prospective study.

INTRODUCTION Prior studies evaluating the relationship between leptin and outcomes in chronic kidney disease patients have shown conflicting results. Our aim was to evaluate the association of serum leptin with all-cause and cardiovascular disease (CVD)-related mortality in stable maintenance hemodialysis patients. MATERIALS AND METHODS We carried out an observational prospective cohort study...

متن کامل

Carotid artery Intima-Media thickness and cardiovascular risk factors in chronic hemodialysis patients

Introduction: Common carotid artery intima-media thickness (CCA-IMT) correlates with cardiovascular mortality in patients under hemodialysis. In this investigation, we evaluated relationship between CCA-IMT with dependent and independent cardiovascular risk factors in chronic hemodialysis patients. Methods: In this cross-sectional study, 51 chronic hemodialysis patients, (31 males and 20 fema...

متن کامل

سطح پلاسمایی لپتین و ارتباط آن با نیاز به اریتروپویتین جهت اصلاح کم‌خونی در بیماران همودیالیزی

Background: Anemia is a common complication accompanied by high morbidity and mortality in hemodialysis patients. Considering the fact that the reduction of erythropoietin (EPO) synthesis is the main cause of uremic anemia, receiving recombinant human erythropoietin (rHuEPO) can improve the condition in these patients. Some of these hemodialysis patients, however, have acceptable hemoglobin lev...

متن کامل

بررسی ارتباط لپتین سرم با شاخص‌های آزمایشگاهی و انتروپومتریک سوء تغذیه در بیماران تحت همودیالیز

  Background and Aim: Protein- energy malnutrition is a major problem and one of the risk factors in increasing mortality in hemodialysis patients. Since there is not any single index in the evaluation of nutritional status in these patients, leptin can be used as one of the parameters in this process. In this study, the correlation between serum leptin and biochemical and anthropometric parame...

متن کامل

Relationship between neutrophil to lymphocyte ratio and mortality and morbidity of dialysis patients in Birjand, a one-year old follow-up: brief report

Background: Chronic kidney disease is considered as one of the most common health problems in the world. High mortality and morbidity in these patients, are due to cardiovascular disease and infections. Neutrophil to lymphocyte ratio is recently known as an inflammatory marker. This study aimed to determine the ratio of neutrophil to lymphocyte count in hemodialysis patients in Birjand Special ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

دوره 31 2  شماره 

صفحات  -

تاریخ انتشار 2011